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KMID : 0545120030130030400
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Journal of Microbiology and Biotechnology
2003 Volume.13 No. 3 p.400 ~ p.405
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HpkA, a Histidine Protein Kinase Homolog, is Required for Fruiting Body Development in Myxococcus xanthus
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Park SY
Kim JH/Lee BS/Zusman DR/Cho KY
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Abstract
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A gene (hpkA) encoding a histidine protein kinase homolog has been identified in the upstream region of the espAB operon in Myxococcus xanthus. It encodes a 333 amino acid (35952 Da) protein with a histidine protein kinase domain in the region from amino acid 90 to 317. Null mutations in the hpkA gene caused formation of loose irregular fruiting bodies while wild-type strains developed tight hemispherical fruiting bodies under developmental conditions. Sporulation of the hpkA mutant was delayed by at least 12 h compared to that of the wild-type. It appeared that the hpkA mutation increased the expression of the espAB operon by more than 2-fold compared with the wild-type under developmental conditions. Expression of the hpkA gene was low under vegetative conditions but was highly induced under developmental conditions.
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KEYWORD
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